IntEnz

EC 2.8.3.9 - Butyrate—acetoacetate CoA-transferase

IntEnz Enzyme Nomenclature
EC 2.8.3.9

Names

Reaction

• 12961 [IUBMB]
  acetoacetate

  acetoacetate

  Name origin: UniProt - CHECKED (C)

  CHEBI:13705

  Formula: C4H5O3
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  butanoyl-CoA

  butanoyl-CoA

  Name origin: UniProt - CHECKED (C)

  CHEBI:57371

  Formula: C25H38N7O17P3S
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  acetoacetyl-CoA

  acetoacetyl-CoA

  Name origin: UniProt - CHECKED (C)

  CHEBI:57286

  Formula: C25H36N7O18P3S
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  butanoate

  butanoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:17968

  Formula: C4H7O2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

Comments:

Butanoate, acetoacetate and their CoA thioesters are the preferred substrates, but the enzyme also acts, more slowly, on the derivatives of a number of C2 to C6 monocarboxylic acids.

Links to other databases

References

1. Barker, H.A., Jeng, I.-M., Neff, N., Robertson, J.M., Tam, F.K. and Hosaka, S.
   Butyryl-CoA:acetoacetate CoA-transferase from a lysine-fermenting Clostridium.
   J. Biol. Chem. 253 : 1219-1225 (1978). [PMID: 624727]

[EC 2.8.3.9 created 1984]