EC 2.8.3.8 - Acetate CoA-transferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.8.3.8
Names
Accepted name:
acetate CoA-transferase
Other
names:
acetate coenzyme A-transferase
butyryl CoA:acetate CoA transferase
butyryl coenzyme A transferase
succinyl-CoA:acetate CoA transferase
acetyl-CoA:acetoacetate CoA transferase
butyryl CoA:acetate CoA transferase
butyryl coenzyme A transferase
succinyl-CoA:acetate CoA transferase
acetyl-CoA:acetoacetate CoA transferase
Systematic name:
acyl-CoA:acetate CoA-transferase
Reaction
- acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
Comments:
The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate—acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UM-BBD
,
UniPathway
Protein domains and families:
PROSITE:PDOC00980
Gene Ontology:
GO:0008775
CAS Registry Number:
37278-35-6
UniProtKB/Swiss-Prot:
ATOA_ECOLI
ATOA_HAEIN
ATOD_ECOLI
ATOD_HAEIN
YDIF_ECO57
YDIF_ECOLI
References
-
Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity.Biochem. Biophys. Res. Commun. 33 : 902-908 (1968). [PMID: 4884054]
-
Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases.J. Biol. Chem. 280 : 42919-42928 (2005). [PMID: 16253988]
[EC 2.8.3.8 created 1972]