EC 2.8.3.8 - Acetate CoA-transferase

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IntEnz Enzyme Nomenclature
EC 2.8.3.8

Names

Accepted name:
acetate CoA-transferase
Other names:
acetate coenzyme A-transferase
butyryl CoA:acetate CoA transferase
butyryl coenzyme A transferase
succinyl-CoA:acetate CoA transferase
acetyl-CoA:acetoacetate CoA transferase
Systematic name:
acyl-CoA:acetate CoA-transferase

Reaction

Comments:

The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate—acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00980
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008775
CAS Registry Number: 37278-35-6
UniProtKB/Swiss-Prot:

References

  1. Vanderwinkel, E., Furmanski, P., Reeves, H.C. and Ajl, S.J.
    Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity.
    Biochem. Biophys. Res. Commun. 33 : 902-908 (1968). [PMID: 4884054]
  2. Rangarajan, E. S., Li, Y., Ajamian, E., Iannuzzi, P., Kernaghan, S. D., Fraser, M. E., Cygler, M., Matte, A.
    Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases.
    J. Biol. Chem. 280 : 42919-42928 (2005). [PMID: 16253988]

[EC 2.8.3.8 created 1972]