EC 2.8.3.18 - Succinyl-CoA:acetate CoA-transferase

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IntEnz Enzyme Nomenclature
EC 2.8.3.18

Names

Accepted name:
succinyl-CoA:acetate CoA-transferase
Other names:
aarC (gene name)
SCACT
Systematic name:
succinyl-CoA:acetate CoA-transferase

Reaction

Comments:

In acetic acid bacteria the enzyme, which is highly specific, catalyses the conversion of toxic acetate to acetyl-CoA [2,3]. In the hydrogenosomes of some trichomonads the enzyme catalyses the production of acetate [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Steinbuchel, A., Muller, M.
    Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes.
    Mol. Biochem. Parasitol. 20: 57-65 (1986). [PMID: 3090435]
  2. Mullins, E. A., Francois, J. A., Kappock, T. J.
    A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti.
    J. Bacteriol. 190: 4933-4940 (2008). [PMID: 18502856]
  3. Mullins, E. A., Kappock, T. J.
    Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases.
    Biochemistry 51: 8422-8434 (2012). [PMID: 23030530]

[EC 2.8.3.18 created 2013]