EC 2.8.3.15 - Succinyl-CoA:(R)-benzylsuccinate CoA-transferase

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IntEnz Enzyme Nomenclature
EC 2.8.3.15

Names

Accepted name:
succinyl-CoA:(R)-benzylsuccinate CoA-transferase
Other name:
benzylsuccinate CoA-transferase
Systematic name:
succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase

Reaction

Comments:

Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033877
UniProtKB/Swiss-Prot:

References

  1. Leutwein, C. and Heider, J.
    Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria.
    J. Bacteriol. 183 : 4288-4295 (2001). [PMID: 11418570]
  2. Leutwein, C. and Heider, J.
    Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and β-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
    Microbiology 145 : 3265-3271 (1999). [PMID: 10589736]
  3. Leuthner, B. and Heider, J.
    Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of β oxidation of the intermediate benzylsuccinate.
    J. Bacteriol. 182 : 272-277 (2000). [PMID: 10629170]
  4. Heider, J.
    A new familiy of CoA-transferases.
    FEBS Lett. 509 : 345-349 (2001). [PMID: 11749953]

[EC 2.8.3.15 created 2003]