EC 2.8.2.8 - [heparan sulfate]-glucosamine N-sulfotransferase

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IntEnz Enzyme Nomenclature
EC 2.8.2.8

Names

Accepted name:
[heparan sulfate]-glucosamine N-sulfotransferase
Other names:
3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase
3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase
3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase
N-HSST
N-desulfoheparin sulfotransferase
N-heparan sulfate sulfotransferase
PAPS:N-desulfoheparin sulfotransferase
PAPS:DSH sulfotransferase
desulfoheparin sulfotransferase
heparan sulfate 2-N-sulfotransferase
heparan sulfate N-deacetylase/N-sulfotransferase
heparan sulfate N-sulfotransferase
heparan sulfate sulfotransferase
heparin N-sulfotransferase
heparitin sulfotransferase
Systematic name:
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase

Reaction

Comments:

The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015016
CAS Registry Number: 9026-75-9
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Suzuki, S., Trenn, R.H. and Strominger, J.L.
    Separation of specific mucopolysaccharide sulfotransferases.
    Biochim. Biophys. Acta 50: 169-174 (1961).
  2. Eisenman, R.A., Balasubramanian, A.S. and Marx, W.
    3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction.
    Arch. Biochem. Biophys. 119: 387-397 (1967). [PMID: 4964017]
  3. Johnson, A.H. and Baker, J.R.
    The enzymatic sulphation of heparan sulphate by hen's uterus.
    Biochim. Biophys. Acta 320: 341-351 (1973). [PMID: 4270798]

[EC 2.8.2.8 created 1972, modified 2001 (EC 2.8.2.12 created 1972, incorporated 2001)]