EC - Bile-salt sulfotransferase

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IntEnz Enzyme Nomenclature


Accepted name:
bile-salt sulfotransferase
Other names:
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase
bile acid sulfotransferase I
glycolithocholate sulfotransferase
Systematic name:
3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase



The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5β-bile acid glycolithocholate, deoxycholate, 3β-hydroxy-5-cholenoate and dehydroepiandrosterone (3β-hydroxyandrost-5-en-17-one) also act as substrates [see also EC (alcohol sulfotransferase) and EC (glycochenodeoxycholate sulfotransferase)]. May be identical to EC [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047704
CAS Registry Number: 65802-92-8


  1. Chen, L.-J., Bolt, R.J. and Admirand, W.H.
    Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts.
    Biochim. Biophys. Acta 480 : 219-227 (1977). [PMID: 831833]
  2. Barnes, S., Waldrop, R., Crenshaw, J., King, R.J. and Taylor, K.B.
    Evidence for an ordered reaction mechanism for bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate.
    J. Lipid Res. 27 : 1111-1123 (1987). [PMID: 3470420]
  3. Barnes, S., Buchina, E.S., King, R.J., McBurnett, T. and Taylor, K.B.
    Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties.
    J. Lipid Res. 30 : 529-540 (1989). [PMID: 2754334]
  4. Russell, D.W.
    The enzymes, regulation, and genetics of bile acid synthesis.
    Annu. Rev. Biochem. 72 : 137-174 (2003). [PMID: 12543708]

[EC created 1978, modified 2005]