EC 2.8.1.9 - Molybdenum cofactor sulfurtransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.8.1.9

Names

Accepted name:
molybdenum cofactor sulfurtransferase
Other names:
molybdenum cofactor sulfurase
ABA3
HMCS
MoCo sulfurase
MoCo sulfurtransferase
Systematic name:
L-cysteine:molybdenum cofactor sulfurtransferase

Reaction

Cofactor

Comments:

Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008265 , GO:0102867
UniProtKB/Swiss-Prot: (39) [show] [UniProt]

References

  1. Bittner, F., Oreb, M., Mendel, R. R.
    ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.
    J. Biol. Chem. 276 : 40381-40384 (2001). [PMID: 11553608]
  2. Heidenreich, T., Wollers, S., Mendel, R. R., Bittner, F.
    Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
    J. Biol. Chem. 280 : 4213-4218 (2005). [PMID: 15561708]
  3. Wollers, S., Heidenreich, T., Zarepour, M., Zachmann, D., Kraft, C., Zhao, Y., Mendel, R. R., Bittner, F.
    Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
    J. Biol. Chem. 283 : 9642-9650 (2008). [PMID: 18258600]

[EC 2.8.1.9 created 2011, modified 2015]