EC - Thiosulfate—thiol sulfurtransferase

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IntEnz Enzyme Nomenclature


Accepted name:
thiosulfate—thiol sulfurtransferase
Other names:
glutathione-dependent thiosulfate reductase
sulfane reductase
sulfane sulfurtransferase
Systematic name:
thiosulfate:thiol sulfurtransferase



The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050337
CAS Registry Number: 111070-24-7


  1. Peck, H.D. and Fischer, E.
    The oxidation of thiosulfate and phosphorylation in extracts of Thiobacillus thioparus.
    J. Biol. Chem. 237 : 190-197 (1962).
  2. Sido, B. and Koj, A.
    Separation of rhodanese and thiosulfate reductase activities in carp liver extracts.
    Acta Biol. Cracow Ser. Zoo. 15 : 97-103 (1972).
  3. Uhteg, L.C. and Westley, J.
    Purification and steady-state kinetic analysis of yeast thiosulfate reductase.
    Arch. Biochem. Biophys. 195 : 211-222 (1979). [PMID: 383018]

[EC created 1982]