IntEnz

EC 2.8.1.3 - Thiosulfate—thiol sulfurtransferase

IntEnz Enzyme Nomenclature
EC 2.8.1.3

Names

Reaction

• 14505 [IUBMB]
  2

  glutathione

  glutathione

  Name origin: UniProt - CHECKED (C)

  CHEBI:57925

  Formula: C10H16N3O6S
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  thiosulfate

  thiosulfate

  Name origin: UniProt - CHECKED (C)

  CHEBI:33542

  Formula: HO3S2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  glutathione disulfide

  glutathione disulfide

  Name origin: UniProt - CHECKED (C)

  CHEBI:58297

  Formula: C20H30N6O12S2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  hydrogen sulfide

  hydrogen sulfide

  Name origin: UniProt - CHECKED (C)

  CHEBI:29919

  Formula: HS
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  sulfite

  sulfite

  Name origin: UniProt - CHECKED (C)

  CHEBI:17359

  Formula: O3S
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor.

Links to other databases

References

1. Peck, H.D. and Fischer, E.
   The oxidation of thiosulfate and phosphorylation in extracts of Thiobacillus thioparus.
   J. Biol. Chem. 237: 190-197 (1962).
2. Sido, B. and Koj, A.
   Separation of rhodanese and thiosulfate reductase activities in carp liver extracts.
   Acta Biol. Cracow Ser. Zoo. 15: 97-103 (1972).
3. Uhteg, L.C. and Westley, J.
   Purification and steady-state kinetic analysis of yeast thiosulfate reductase.
   Arch. Biochem. Biophys. 195: 211-222 (1979). [PMID: 383018]

[EC 2.8.1.3 created 1982]