EC 2.7.9.6 - Rifampicin phosphotransferase

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IntEnz Enzyme Nomenclature
EC 2.7.9.6

Names

Accepted name:
rifampicin phosphotransferase
Other names:
rifampin phosphotransferase
RPH
Systematic name:
ATP:rifampicin,water 21-O-phosphotransferase

Reaction

Comments:

The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21. The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate-carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Spanogiannopoulos, P., Waglechner, N., Koteva, K., Wright, G. D.
    A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.
    Proc. Natl. Acad. Sci. U.S.A. 111 : 7102-7107 (2014). [PMID: 24778229]
  2. Stogios, P. J., Cox, G., Spanogiannopoulos, P., Pillon, M. C., Waglechner, N., Skarina, T., Koteva, K., Guarne, A., Savchenko, A., Wright, G. D.
    Rifampin phosphotransferase is an unusual antibiotic resistance kinase.
    Nat Commun 7 : 11343 (2016). [PMID: 27103605]

[EC 2.7.9.6 created 2018]