EC - Pyruvate, water dikinase

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IntEnz Enzyme Nomenclature


Accepted name:
pyruvate, water dikinase
Other names:
PEP synthetase
phoephoenolpyruvate synthetase
phosphoenolpyruvate synthase
phosphoenolpyruvic synthase
phosphopyruvate synthetase
pyruvate-water dikinase (phosphorylating)
pyruvate,water dikinase
Systematic name:
ATP:pyruvate, water phosphotransferase




A manganese protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00527
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008986
CAS Registry Number: 9013-09-6
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Berman, K.M. and Cohn, M.
    Phosphoenolpyruvate synthetase of Escherichia coli. Purification, some properties, and the role of divalent metal ions.
    J. Biol. Chem. 245 : 5309-5318 (1970). [PMID: 4319237]
  2. Berman, K.M. and Cohn, M.
    Phosphoenolpyruvate synthetase. Partial reactions studied with adenosine triphosphate analogues and the inorganic phosphate-H218O exchange reaction.
    J. Biol. Chem. 245 : 5319-5325 (1970). [PMID: 4319238]
  3. Cooper, R.A. and Kornberg, H.L.
    Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli.
    Biochim. Biophys. Acta 104 : 618-620 (1965). [PMID: 5322808]
  4. Cooper, R.A. and Kornberg, H.L.
    Phosphoenolpyruvate synthetase.
    Methods Enzymol. 13 : 309-314 (1969).

[EC created 1976]