EC 2.7.8.45 - Teichoic acid glycerol-phosphate transferase

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IntEnz Enzyme Nomenclature
EC 2.7.8.45

Names

Accepted name:
teichoic acid glycerol-phosphate transferase
Other names:
tarF (gene name) [ambiguous]
teichoic acid glycerol-phosphate primase
Systematic name:
CDP-glycerol:4-O-[(2R)-1-glycerophospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase

Reaction

Comments:

Involved in the biosynthesis of teichoic acid linkage units in the cell walls of some bacteria such as Staphylococcus aureus. This enzyme adds a second glycerol unit to the disaccharide linker of the teichoic acid. cf. EC 2.7.8.12, teichoic acid poly(glycerol phosphate) polymerase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Brown, S., Zhang, Y. H., Walker, S.
    A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
    Chem. Biol. 15: 12-21 (2008). [PMID: 18215769]
  2. Brown, S., Meredith, T., Swoboda, J., Walker, S.
    Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
    Chem. Biol. 17: 1101-1110 (2010). [PMID: 21035733]

[EC 2.7.8.45 created 2017]