EC 2.7.8.44 - Teichoic acid glycerol-phosphate primase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.7.8.44

Names

Accepted name:
teichoic acid glycerol-phosphate primase
Other names:
Tag primase
CDP-glycerol:glycerophosphate glycerophosphotransferase
tagB (gene name)
tarB (gene name)
Systematic name:
CDP-glycerol:N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase

Reaction

Comments:

Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. This enzyme adds the first glycerol unit to the disaccharide linker of the teichoic acid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Bhavsar, A. P., Truant, R., Brown, E. D.
    The TagB protein in Bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in vitro.
    J. Biol. Chem. 280: 36691-36700 (2005). [PMID: 16150696]
  2. Ginsberg, C., Zhang, Y. H., Yuan, Y., Walker, S.
    In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis.
    ACS Chem. Biol. 1: 25-28 (2006). [PMID: 17163636]
  3. Brown, S., Zhang, Y. H., Walker, S.
    A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
    Chem. Biol. 15: 12-21 (2008). [PMID: 18215769]

[EC 2.7.8.44 created 2016]