EC - Cardiolipin synthase (CMP-forming)

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IntEnz Enzyme Nomenclature


Accepted name:
cardiolipin synthase (CMP-forming)
Systematic name:
CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming)




The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (13) [show] [UniProt]


  1. Schlame, M., Hostetler, K. Y.
    Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement.
    J. Biol. Chem. 266 : 22398-22403 (1991). [PMID: 1657995]
  2. Nowicki, M., Muller, F., Frentzen, M.
    Cardiolipin synthase of Arabidopsis thaliana.
    FEBS Lett. 579 : 2161-2165 (2005). [PMID: 15811335]
  3. Houtkooper, R. H., Akbari, H., van Lenthe, H., Kulik, W., Wanders, R. J., Frentzen, M., Vaz, F. M.
    Identification and characterization of human cardiolipin synthase.
    FEBS Lett. 580 : 3059-3064 (2006). [PMID: 16678169]
  4. Sandoval-Calderon, M., Geiger, O., Guan, Z., Barona-Gomez, F., Sohlenkamp, C.
    A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria.
    J. Biol. Chem. 284 : 17383-17390 (2009). [PMID: 19439403]
  5. Sarma, P. V., Srikanth, L., Venkatesh, K., Murthy, P. S., Sarma, P. U.
    Isolation, purification and characterization of Cardiolipin synthase from Mycobacterium phlei {PRIVATE}.
    Bioinformation 9 : 690-695 (2013). [PMID: 23930021]

[EC created 2014]