EC 2.7.8.35 - UDP-N-acetylglucosamine—decaprenyl-phosphate N-acetylglucosaminephosphotransferase

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IntEnz Enzyme Nomenclature
EC 2.7.8.35

Names

Accepted name:
UDP-N-acetylglucosamine—decaprenyl-phosphate N-acetylglucosaminephosphotransferase
Other names:
GlcNAc-1-phosphate transferase
UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase
WecA
WecA transferase
Systematic name:
UDP-N-acetyl-α-D-glucosamine:trans,octacis-decaprenyl-phosphate N-acetylglucosaminephosphotransferase

Reaction

Comments:

Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis. This enzyme catalyses the synthesis of monotrans,octacis-decaprenyl-N-acetyl-α-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Jin, Y., Xin, Y., Zhang, W., Ma, Y.
    Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis.
    FEMS Microbiol. Lett. 310 : 54-61 (2010). [PMID: 20637039]

[EC 2.7.8.35 created 2012]