EC - Carboxyvinyl-carboxyphosphonate phosphorylmutase

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IntEnz Enzyme Nomenclature


Accepted name:
carboxyvinyl-carboxyphosphonate phosphorylmutase
Systematic name:
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)



Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008807
CAS Registry Number: 122799-57-9


  1. Pollack, S.J., Freeman, S., Pompliano, D.L., Knowles, J.R.
    Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
    Eur. J. Biochem. 209 : 735-743 (1992). [PMID: 1330557]
  2. Anzai, H., Murakami, T., Imai, S., Satoh, A., Nagaoka, K. and Thompson, C.J.
    Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.
    J. Bacteriol. 169 : 3482-3488 (1987). [PMID: 3611020]

[EC created 1999]