EC 2.7.8.17 - UDP-N-acetylglucosamine—lysosomal-enzyme N-acetylglucosaminephosphotransferase

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IntEnz Enzyme Nomenclature
EC 2.7.8.17

Names

Accepted name:
UDP-N-acetylglucosamine—lysosomal-enzyme N-acetylglucosaminephosphotransferase
Other names:
N-acetylglucosaminyl phosphotransferase
N-acetylglucosaminylphosphotransferase
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase
UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase
UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase
UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase
lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase
Systematic name:
UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase

Reaction

Comments:

Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003976
CAS Registry Number: 84012-69-1
UniProtKB/Swiss-Prot:

References

  1. Reitman, M.L. and Kornfeld, S.
    UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes.
    J. Biol. Chem. 256 : 4275-4281 (1981). [PMID: 6452459]
  2. Reitman, M.L. and Kornfeld, S.
    Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes.
    J. Biol. Chem. 256 : 11977-11980 (1981). [PMID: 6457829]
  3. Waheed, A., Hasilik, A. and von Figura, K.
    UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme.
    J. Biol. Chem. 257 : 12322-12331 (1982). [PMID: 6288715]
  4. Waheed, A., Pohlmann, R., Hasilik, A. and von Figura, K.
    Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes.
    J. Biol. Chem. 256 : 4150-4152 (1981). [PMID: 6260788]

[EC 2.7.8.17 created 1984]