EC 2.7.8.13 - Phospho-N-acetylmuramoyl-pentapeptide-transferase

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IntEnz Enzyme Nomenclature
EC 2.7.8.13

Names

Accepted name:
phospho-N-acetylmuramoyl-pentapeptide-transferase
Other names:
MraY transferase
UDP-MurNAc-L-Ala-D-γ-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase
UDP-MurNAc-Ala-γDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase
phospho-N-acetylmuramoyl pentapeptide translocase
phospho-MurNAc-pentapeptide transferase
phospho-NAc-muramoyl-pentapeptide translocase (UMP)
phosphoacetylmuramoylpentapeptide translocase
phosphoacetylmuramoylpentapeptidetransferase
UDP-MurNAc-pentapeptide phosphotransferase
Systematic name:
UDP-MurAc(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase

Reaction

Comments:

In Gram-negative and some Gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans,octacis-undecaprenol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC01046
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051992 , GO:0008963
CAS Registry Number: 9068-50-2
UniProtKB/Swiss-Prot: (716) [show] [UniProt]

References

  1. Heydanek, M.G., Jr. and Neuhaus, F.C.
    The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase.
    Biochemistry 8 : 1474-1481 (1969). [PMID: 5805290]
  2. Higashi, Y., Strominger, J.L. and Sweeley, C.C.
    Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol.
    Proc. Natl. Acad. Sci. USA 57 : 1878-1884 (1967). [PMID: 5231417]
  3. Struve, W.G., Sinha, R.K. and Neuhaus, F.C.
    On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate).
    Biochemistry 5 : 82-93 (1966). [PMID: 5938956]
  4. van Heijenoort, J.
    Recent advances in the formation of the bacterial peptidoglycan monomer unit.
    Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]

[EC 2.7.8.13 created 1972, modified 2002]