EC - 2'-5' oligoadenylate synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
2'-5' oligoadenylate synthase
Other name:
Systematic name:
ATP:ATP adenylyltransferase (2'-5' linkages-forming)



The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0001730
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Kerr, I. M., Brown, R. E.
    pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.
    Proc. Natl. Acad. Sci. U.S.A. 75 : 256-260 (1978). [PMID: 272640]
  2. Martin, E. M., Birdsall, N. J., Brown, R. E., Kerr, I. M.
    Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material.
    Eur. J. Biochem. 95 : 295-307 (1979). [PMID: 456356]
  3. Hartmann, R., Justesen, J., Sarkar, S. N., Sen, G. C., Yee, V. C.
    Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase.
    Mol. Cell 12 : 1173-1185 (2003). [PMID: 14636576]
  4. Hovanessian, A. G., Justesen, J.
    The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
    Biochimie 89 : 779-788 (2007). [PMID: 17408844]

[EC created 2013]