EC 2.7.7.78 - GDP-D-glucose phosphorylase

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IntEnz Enzyme Nomenclature
EC 2.7.7.78

Names

Accepted name:
GDP-D-glucose phosphorylase
Systematic name:
GDP:α-D-glucose 1-phosphate guanylyltransferase

Reaction

Comments:

The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-α-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0080048
UniProtKB/Swiss-Prot:

References

  1. Adler, L. N., Gomez, T. A., Clarke, S. G., Linster, C. L.
    A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
    J. Biol. Chem. 286 : 21511-21523 (2011). [PMID: 21507950]

[EC 2.7.7.78 created 2011]