EC 2.7.7.75 - Molybdopterin adenylyltransferase

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IntEnz Enzyme Nomenclature
EC 2.7.7.75

Names

Accepted name:
molybdopterin adenylyltransferase
Other names:
MogA
Cnx1 [ambiguous]
Systematic name:
ATP:molybdopterin adenylyltransferase

Reaction

Cofactor

Comments:

Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). The reaction requires a divalent cation such as Mg2+ or Mn2+.

Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. Formerly EC 2.7.7.n5.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0061598
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Nichols, J. D., Rajagopalan, K. V.
    In vitro molybdenum ligation to molybdopterin using purified components.
    J. Biol. Chem. 280: 7817-7822 (2005). [PMID: 15632135]
  2. Kuper, J., Palmer, T., Mendel, R. R., Schwarz, G.
    Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization.
    Proc. Natl. Acad. Sci. USA 97: 6475-6480 (2000). [PMID: 10823911]
  3. Llamas, A., Mendel, R. R., Schwarz, G.
    Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion.
    J. Biol. Chem. 279: 55241-55246 (2004). [PMID: 15504727]

[EC 2.7.7.75 created 2011]