IntEnz

EC 2.7.7.70 - D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

IntEnz Enzyme Nomenclature
EC 2.7.7.70

Names

Reaction

• 27465 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  D-glycero-β-D-manno-heptose 1-phosphate

  D-glycero-beta-D-manno-heptose 1-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:61593

  Formula: C7H13O10P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  =

  ADP-D-glycero-β-D-manno-heptose

  ADP-D-glycero-beta-D-manno-heptose

  Name origin: UniProt - CHECKED (C)

  CHEBI:59967

  Formula: C17H25N5O16P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  diphosphate

  diphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:33019

  Formula: HO7P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

Comments:

The bifunctional protein hldE includes D-glycero-β-D-manno-heptose-7-phosphate kinase and D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167). The enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.

Links to other databases

References

1. Valvano, M. A., Marolda, C. L., Bittner, M., Glaskin-Clay, M., Simon, T. L., Klena, J. D.
   The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose.
   J. Bacteriol. 182: 488-497 (2000). [PMID: 10629197]
2. Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M. A., Messner, P.
   Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli.
   J. Bacteriol. 184: 363-369 (2002). [PMID: 11751812]
3. Valvano, M. A., Messner, P., Kosma, P.
   Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
   Microbiology 148: 1979-1989 (2002). [PMID: 12101286]
4. Wang, L., Huang, H., Nguyen, H. H., Allen, K. N., Mariano, P. S., Dunaway-Mariano, D.
   Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
   Biochemistry 49: 1072-1081 (2010). [PMID: 20050615]

[EC 2.7.7.70 created 2010]