EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.7 - Nucleotidyltransferases
EC 2.7.7.70 - D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.7.70
Names
Accepted name:
D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase
Other
names:
D-β-D-heptose 7-phosphate kinase/D-β-D-heptose 1-phosphate adenylyltransferase
D-glycero-D-manno-heptose-1β-phosphate adenylyltransferase
hldE
rfaE
D-glycero-D-manno-heptose-1β-phosphate adenylyltransferase
hldE
rfaE
Systematic name:
ATP:D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase
Reaction
- D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate
Comments:
The bifunctional protein hldE includes D-glycero-β-D-manno-heptose-7-phosphate kinase and D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167). The enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.
Links to other databases
References
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The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose.J. Bacteriol. 182 : 488-497 (2000). [PMID: 10629197]
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Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli.J. Bacteriol. 184 : 363-369 (2002). [PMID: 11751812]
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Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.Microbiology 148 : 1979-1989 (2002). [PMID: 12101286]
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Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).Biochemistry 49 : 1072-1081 (2010). [PMID: 20050615]
[EC 2.7.7.70 created 2010]