EC - D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase
Other names:
D-β-D-heptose 7-phosphate kinase/D-β-D-heptose 1-phosphate adenylyltransferase
D-glycero-D-manno-heptose-1β-phosphate adenylyltransferase
Systematic name:
ATP:D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase



The bifunctional protein hldE includes D-glycero-β-D-manno-heptose-7-phosphate kinase and D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC The enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (200) [show] [UniProt]


  1. Valvano, M. A., Marolda, C. L., Bittner, M., Glaskin-Clay, M., Simon, T. L., Klena, J. D.
    The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose.
    J. Bacteriol. 182 : 488-497 (2000). [PMID: 10629197]
  2. Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M. A., Messner, P.
    Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli.
    J. Bacteriol. 184 : 363-369 (2002). [PMID: 11751812]
  3. Valvano, M. A., Messner, P., Kosma, P.
    Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
    Microbiology 148 : 1979-1989 (2002). [PMID: 12101286]
  4. Wang, L., Huang, H., Nguyen, H. H., Allen, K. N., Mariano, P. S., Dunaway-Mariano, D.
    Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
    Biochemistry 49 : 1072-1081 (2010). [PMID: 20050615]

[EC created 2010]