EC 2.7.7.67 - CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

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IntEnz Enzyme Nomenclature
EC 2.7.7.67

Names

Accepted name:
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Other names:
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase
CTP:2,3-GG-GP ether cytidylyltransferase
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase
CDP-unsaturated archaeol synthase
CDP-archaeol synthase [incorrect]
carS (gene name)
Systematic name:
CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase

Reaction

Cofactors

Comments:

This enzyme catalyses one of the steps in the biosynthesis of polar lipids in Archaea, which are characterized by having an sn-glycero-1-phosphate backbone rather than an sn-glycero-3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 329791-09-5
UniProtKB/Swiss-Prot: (54) [show] [UniProt]

References

  1. Morii, H., Nishihara, M. and Koga, Y.
    CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
    J. Biol. Chem. 275: 36568-36574 (2000). [PMID: 10960477]
  2. Morii, H. and Koga, Y.
    CDP-2,3-di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.
    J. Bacteriol. 185: 1181-1189 (2003). [PMID: 12562787]
  3. Jain, S., Caforio, A., Fodran, P., Lolkema, J. S., Minnaard, A. J., Driessen, A. J.
    Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea.
    Chem. Biol. 21: 1392-1401 (2014). [PMID: 25219966]

[EC 2.7.7.67 created 2009, modified 2014]