EC 184.108.40.206 - UTP-monosaccharide-1-phosphate uridylyltransferase
IntEnz Enzyme Nomenclature
- UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide
Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates .
Links to other databases
UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.J. Biol. Chem. 279 : 45728-45736 (2004). [PMID: 15326166]
Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.J. Biol. Chem. 249 : 7832-7840 (1974). [PMID: 4430676]
[EC 220.127.116.11 created 2006]