EC 2.7.7.64 - UTP-monosaccharide-1-phosphate uridylyltransferase

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IntEnz Enzyme Nomenclature
EC 2.7.7.64

Names

Accepted name:
UTP-monosaccharide-1-phosphate uridylyltransferase
Other names:
UDP-sugar pyrophosphorylase
PsUSP
USP
Systematic name:
-

Reaction

Cofactor

Comments:

Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051748
UniProtKB/Swiss-Prot:

References

  1. Kotake, T., Yamaguchi, D., Ohzono, H., Hojo, S., Kaneko, S., Ishida, H.K. and Tsumuraya, Y.
    UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.
    J. Biol. Chem. 279 : 45728-45736 (2004). [PMID: 15326166]
  2. Rudick, V.L. and Weisman, R.A.
    Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.
    J. Biol. Chem. 249 : 7832-7840 (1974). [PMID: 4430676]

[EC 2.7.7.64 created 2006]