EC - DNA-directed RNA polymerase

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IntEnz Enzyme Nomenclature


Accepted name:
DNA-directed RNA polymerase
Other names:
C RNA formation factors
C ribonucleic acid formation factors
DNA-dependent RNA nucleotidyltransferase
DNA-dependent RNA polymerase
DNA-dependent ribonucleate nucleotidyltransferase
RNA nucleotidyltransferase
RNA nucleotidyltransferase (DNA-directed)
RNA polymerase
RNA polymerase I
RNA polymerase II
RNA polymerase III
RNA transcriptase
deoxyribonucleic acid-dependent ribonucleic acid polymerase
ribonucleate nucleotidyltransferase
ribonucleate polymerase
ribonucleic acid nucleotidyltransferase
ribonucleic acid polymerase
ribonucleic acid transcriptase
ribonucleic polymerase
ribonucleic transcriptase
Systematic name:
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)



Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to α-amanitin, and the type of RNA synthesized. See also EC (polynucleotide adenyltransferase) and EC (RNA-directed RNA polymerase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00106 , PROSITE:PDOC00410 , PROSITE:PDOC00411 , PROSITE:PDOC00790 , PROSITE:PDOC00854 , PROSITE:PDOC00855 , PROSITE:PDOC00856 , PROSITE:PDOC00889 , PROSITE:PDOC00896
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003899
CAS Registry Number: 9014-24-8
UniProtKB/Swiss-Prot: (1000) [show] [UniProt]


  1. Krakow, J.S. and Ochoa, S.
    RNA polymerase from Azotobacter vinelandii.
    Methods Enzymol. 6 : 11-17 (1963).
  2. Mans, R.J. and Walter, T.J.
    Transfer RNA-primed oligoadenylate synthesis in maize seedlings. II. Primer, substrate and metal specificities and size of product.
    Biochim. Biophys. Acta 247 : 113-121 (1971). [PMID: 4946277]
  3. Roeder, R.G.
    In: Losick, R. and Chamberlin, M. (Eds.) RNA Polymerase , Cold Spring Harbor Laboratory , 1976 , 285
  4. Sheldon, R., Jurale, C.and Kates, J.
    Detection of polyadenylic acid sequences in viral and eukaryotic RNA(poly(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4).
    Proc. Natl. Acad. Sci. USA 69 : 417-421 (1972). [PMID: 4501121]
  5. Weaver, R.F., Blatti, S.P. and Rutter, W.J.
    Molecular structures of DNA-dependent RNA polymerases (II) from calf thymus and rat liver.
    Proc. Natl. Acad. Sci. USA 68 : 2994-2999 (1971). [PMID: 5289245]

[EC created 1961, modified 1981, modified 1982, modified 1989]