EC - RNA-directed DNA polymerase

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IntEnz Enzyme Nomenclature


Accepted name:
RNA-directed DNA polymerase
Other names:
DNA nucleotidyltransferase (RNA-directed)
RNA revertase
RNA-dependent DNA polymerase
RNA-dependent deoxyribonucleate nucleotidyltransferase
RNA-instructed DNA polymerase
reverse transcriptase
Systematic name:
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)



Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC DNA-directed DNA polymerase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50878
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003964
CAS Registry Number: 9068-38-6
UniProtKB/Swiss-Prot: (328) [show] [UniProt]


  1. Baltimore, D.
    RNA-dependent DNA polymerase in virions of RNA tumour viruses.
    Nature 226 : 1209-1211 (1970). [PMID: 4316300]
  2. Temin, H. and Mizutani, S.
    RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
    Nature 226 : 1211-1213 (1970). [PMID: 4316301]

[EC created 1981, modified 1982]