EC 2.7.7.4
- Sulfate adenylyltransferase
IntEnz Enzyme Nomenclature
EC 2.7.7.4
Names
Accepted name:
sulfate adenylyltransferase
Other
names:
ATP sulfurylase
ATP-sulfurylase
adenosine-5'-triphosphate sulfurylase
adenosinetriphosphate sulfurylase
adenylylsulfate pyrophosphorylase
sulfurylase
sulfate adenylate transferase
Systematic name:
ATP:sulfate adenylyltransferase
Reaction
-
ATP + sulfate = diphosphate + adenylyl sulfate
Comments:
The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25).
Links to other databases
CAS Registry Number:
9012-39-9
APS1_ARATH
APS2-2_ARATH
APS2_ARATH
APS3_ARATH
APS4_ARATH
CYSD1_ALKEH
CYSD1_CHRSD
CYSD1_MARN8
CYSD1_SHESH
CYSD2_ALKEH
CYSD2_CHRSD
CYSD2_MARN8
CYSD2_SHESH
CYSD_ACIAD
CYSD_ACIBS
CYSD_ACIBY
CYSD_AERHH
CYSD_AERS4
CYSD_AGRFC
CYSD_AGRRK
CYSD_AGRVS
CYSD_AKKM8
CYSD_ALIB4
CYSD_ALIF1
CYSD_ALIFM
CYSD_ALISL
CYSD_AZOVD
CYSD_BACFN
CYSD_BACFR
CYSD_BACTN
CYSD_BAUCH
CYSD_BRASB
CYSD_BRASO
CYSD_BRUA2
CYSD_BRUA4
CYSD_BRUAB
CYSD_BRUC2
CYSD_BRUMB
CYSD_BRUME
CYSD_BRUO2
CYSD_BRUSI
CYSD_BRUSU
CYSD_BUCA5
CYSD_BUCAI
CYSD_BUCAT
CYSD_BURL3
CYSD_CAUSK
CYSD_CAUVC
CYSD_CHESB
CYSD_CHLPM
CYSD_CHRVO
CYSD_CITBB
CYSD_CITK8
CYSD_COLP3
CYSD_CROS8
CYSD_ECO24
CYSD_ECO27
CYSD_ECO45
CYSD_ECO55
CYSD_ECO57
CYSD_ECO5E
CYSD_ECO7I
CYSD_ECO81
CYSD_ECO8A
CYSD_ECOBW
CYSD_ECODH
CYSD_ECOHS
CYSD_ECOK1
CYSD_ECOL5
CYSD_ECOL6
CYSD_ECOLC
CYSD_ECOLI
CYSD_ECOLU
CYSD_ECOSE
CYSD_ECOSM
CYSD_ECOUT
CYSD_ENT38
CYSD_ERWT9
CYSD_ESCF3
CYSD_GEODF
CYSD_GEOLS
CYSD_GEOMG
CYSD_GEOSM
CYSD_GEOUR
CYSD_HAHCH
CYSD_HALHL
CYSD_HYPNA
CYSD_KLEP3
CYSD_KLEP7
CYSD_MAGMM
CYSD_MARMM
CYSD_MARMS
CYSD_METC4
CYSD_METCA
CYSD_METEP
CYSD_METNO
CYSD_METPB
CYSD_METRJ
CYSD_METS4
CYSD_MYCBO
CYSD_MYCBP
CYSD_MYCGI
CYSD_MYCSJ
CYSD_MYCSK
CYSD_MYCSS
CYSD_MYCTA
CYSD_MYCTO
CYSD_MYCTU
CYSD_MYCVP
CYSD_MYXXD
CYSD_NOCFA
CYSD_PARD8
CYSD_PECAS
CYSD_PECCP
CYSD_PHOLL
CYSD_PHOPR
CYSD_PHOV8
CYSD_PROMH
CYSD_PSE14
CYSD_PSEA6
CYSD_PSEA7
CYSD_PSEA8
CYSD_PSEAB
CYSD_PSEAE
CYSD_PSEE4
CYSD_PSEF5
CYSD_PSEFS
CYSD_PSEMY
CYSD_PSEP1
CYSD_PSEPF
CYSD_PSEPG
CYSD_PSEPK
CYSD_PSEPW
CYSD_PSESM
CYSD_PSET1
CYSD_PSEU2
CYSD_PSEU5
CYSD_PSYIN
CYSD_RHIE6
CYSD_RHIEC
CYSD_RHIL3
CYSD_RHILO
CYSD_RHILW
CYSD_RHIME
CYSD_RHITR
CYSD_RHOP5
CYSD_RHOPB
CYSD_RHORT
CYSD_SACD2
CYSD_SALA4
CYSD_SALAR
CYSD_SALCH
CYSD_SALDC
CYSD_SALEP
CYSD_SALG2
CYSD_SALHS
CYSD_SALNS
CYSD_SALPA
CYSD_SALPB
CYSD_SALPK
CYSD_SALSV
CYSD_SALTI
CYSD_SALTY
CYSD_SERP5
CYSD_SHEAM
CYSD_SHEB2
CYSD_SHEB5
CYSD_SHEB8
CYSD_SHEB9
CYSD_SHEDO
CYSD_SHEFN
CYSD_SHEHH
CYSD_SHELP
CYSD_SHEON
CYSD_SHEPA
CYSD_SHEPC
CYSD_SHEPW
CYSD_SHESA
CYSD_SHESM
CYSD_SHESR
CYSD_SHESW
CYSD_SHEWM
CYSD_SHIB3
CYSD_SHIBS
CYSD_SHIDS
CYSD_SHIF8
CYSD_SHIFL
CYSD_SHISS
CYSD_SODGM
CYSD_SULDN
CYSD_SULNB
CYSD_SYNC1
CYSD_VIBA3
CYSD_VIBC3
CYSD_VIBCB
CYSD_VIBCH
CYSD_VIBCM
CYSD_VIBPA
CYSD_VIBVU
CYSD_VIBVY
CYSD_XANAC
CYSD_XANC5
CYSD_XANC8
CYSD_XANCB
CYSD_XANCP
CYSD_XANOM
CYSD_XANOP
CYSD_XYLFA
CYSD_XYLFT
CYSD_YERE8
CYSD_YERP3
CYSD_YERPA
CYSD_YERPB
CYSD_YERPE
CYSD_YERPG
CYSD_YERPN
CYSD_YERPP
CYSD_YERPS
CYSD_YERPY
CYSD_ZYMMO
CYSNC_MYCTO
CYSNC_MYCTU
CYSNC_PSEAE
CYSNC_RHOBA
CYSNC_XYLFA
CYSNC_XYLFT
CYSN_AERHH
CYSN_AERS4
CYSN_AGRFC
CYSN_AGRRK
CYSN_ALIB4
CYSN_ALIF1
CYSN_ALIFM
CYSN_ALISL
CYSN_ALTMD
CYSN_BACFN
CYSN_BACFR
CYSN_BACTN
CYSN_BUCA5
CYSN_BUCAI
CYSN_BUCAT
CYSN_CELJU
CYSN_CHRSD
CYSN_CHRVO
CYSN_CITK8
CYSN_COLP3
CYSN_CROS8
CYSN_ECO24
CYSN_ECO27
CYSN_ECO45
CYSN_ECO55
CYSN_ECO57
CYSN_ECO5E
CYSN_ECO7I
CYSN_ECO81
CYSN_ECO8A
CYSN_ECOBW
CYSN_ECODH
CYSN_ECOHS
CYSN_ECOK1
CYSN_ECOL5
CYSN_ECOL6
CYSN_ECOLC
CYSN_ECOLI
CYSN_ECOLU
CYSN_ECOSE
CYSN_ECOSM
CYSN_ECOUT
CYSN_ERWT9
CYSN_ESCF3
CYSN_FRAT1
CYSN_FRATN
CYSN_FRATT
CYSN_FRATW
CYSN_LARHH
CYSN_METC4
CYSN_METEP
CYSN_METPB
CYSN_PHOLL
CYSN_PHOPR
CYSN_PSEA6
CYSN_PSYIN
CYSN_RHIME
CYSN_RHITR
CYSN_SACD2
CYSN_SALA4
CYSN_SALAR
CYSN_SALCH
CYSN_SALDC
CYSN_SALEP
CYSN_SALG2
CYSN_SALHS
CYSN_SALNS
CYSN_SALPA
CYSN_SALPB
CYSN_SALPC
CYSN_SALPK
CYSN_SALSV
CYSN_SALTI
CYSN_SALTY
CYSN_SHEON
CYSN_SHEWM
CYSN_SHIB3
CYSN_SHIBS
CYSN_SHIDS
CYSN_SHIF8
CYSN_SHIFL
CYSN_SHISS
CYSN_SODGM
CYSN_SULNB
CYSN_TERTT
CYSN_TOLAT
CYSN_VIBA3
CYSN_VIBC3
CYSN_VIBCB
CYSN_VIBCH
CYSN_VIBCM
CYSN_VIBPA
CYSN_VIBVU
CYSN_VIBVY
CYSN_YERE8
CYSN_YERP3
CYSN_YERPE
CYSN_YERPS
MET3_ASHGO
MET3_ASPCL
MET3_ASPFU
MET3_ASPNG
MET3_ASPOR
MET3_ASPTE
MET3_ASPTN
MET3_CANAL
MET3_CANGA
MET3_CHAGB
MET3_COCIM
MET3_CRYNB
MET3_CRYNH
MET3_CRYNJ
MET3_DEBHA
MET3_EMENI
MET3_GIBZE
MET3_KLULA
MET3_MUCCL
MET3_NEOFI
MET3_NEUCR
MET3_PENCH
MET3_PHANO
MET3_SCHPO
MET3_USTMA
MET3_YARLI
MET3_YEAST
MMCV_STRLA
NODP_AZOBR
NODP_RHIME
NODP_RHIS3
NODP_RHISB
NODP_RHITR
NODQ_AZOBR
NODQ_RHIME
NODQ_RHIS3
NODQ_RHISB
NODQ_RHITR
PAPS1_CAVPO
PAPS1_HUMAN
PAPS1_MOUSE
PAPS2-2_HUMAN
PAPS2_HUMAN
PAPS2_MOUSE
PAPSS_URECA
SAT1_BACSU
SAT2_BACSU
SATC1_SORC5
SATC2_SORC5
SATC_AQUAE
SAT_ACAM1
SAT_AERPE
SAT_ALCBS
SAT_ALLVD
SAT_ARCFU
SAT_BACAA
SAT_BACAC
SAT_BACAH
SAT_BACAN
SAT_BACC0
SAT_BACC1
SAT_BACC2
SAT_BACC3
SAT_BACC4
SAT_BACC7
SAT_BACCN
SAT_BACCQ
SAT_BACCR
SAT_BACCZ
SAT_BACHK
SAT_BACLD
SAT_BACMK
SAT_BACP2
SAT_BACSK
SAT_BACVZ
SAT_CARHZ
SAT_CENSY
SAT_CHLAA
SAT_CHLCH
SAT_CHLPB
SAT_CHLSY
SAT_CHLTE
SAT_DEIDV
SAT_DEIGD
SAT_DEIRA
SAT_DESAL
SAT_DESAP
SAT_DESDA
SAT_DESRM
SAT_ENTHI
SAT_GEOKA
SAT_GEOSW
SAT_GEOTN
SAT_GLOVI
SAT_HALOH
SAT_HYPBU
SAT_IGNH4
SAT_LACPL
SAT_LYSSC
SAT_MICAN
SAT_NEOYE
SAT_NITMS
SAT_NOSP7
SAT_OCEIH
SAT_PELPB
SAT_PELTS
SAT_PERMH
SAT_PETMO
SAT_POPEU
SAT_PSYA2
SAT_PSYCK
SAT_PSYWF
SAT_PYRAB
SAT_RIFPS
SAT_RIPO1
SAT_RUBXD
SAT_RUTMC
SAT_STACT
SAT_STAEQ
SAT_STAES
SAT_STAHJ
SAT_STAMF
SAT_STAS1
SAT_SYMTH
SAT_SYNE7
SAT_SYNFM
SAT_SYNJA
SAT_SYNP2
SAT_SYNP6
SAT_SYNY3
SAT_THEON
SAT_THIDA
SAT_TRIEI
SAT_TRIV2
SAT_VESOH
References
-
Bandurski, R.S., Wilson, L.G. and Squires, C.L.
The mechanism of "active sulfate" formation.
J. Am. Chem. Soc.
78
:
6408-6409
(1956).
-
Hilz, H. and Lipmann, F.
The enzymatic activation of sulfate.
Proc. Natl. Acad. Sci. USA
41
:
880-890
(1955).
[PMID:
16589765]
-
Venkatachalam, K.V., Akita, H., Strott, C.
Molecular cloning, expression and characterization of human bifunctional 3'-phosphoadenosine-5'-phosphosulfate synthase and its functional domains.
J. Biol. Chem.
273
:
19311-19320
(1998).
[PMID:
9668121]
[EC 2.7.7.4 created 1961, modified 1999]