EC - Pantetheine-phosphate adenylyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
pantetheine-phosphate adenylyltransferase
Other names:
3'-dephospho-CoA pyrophosphorylase
dephospho-CoA pyrophosphorylase
dephospho-coenzyme A pyrophosphorylase
pantetheine phosphate adenylyltransferase
Systematic name:
ATP:pantetheine-4'-phosphate adenylyltransferase



The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC, glucosamine-1-phosphate N-acetyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004595
CAS Registry Number: 9026-99-7
UniProtKB/Swiss-Prot: (682) [show] [UniProt]


  1. Hoagland, M.B. and Novelli, G.D.
    Biosynthesis of coenzyme A from phosphopantetheine and of pantetheine from pantothenate.
    J. Biol. Chem. 207 : 767-773 (1954).
  2. Novelli, G.D.
    Enzymatic synthesis and structure of CoA.
    Fed. Proc. 12 : 675-682 (1953).
  3. Martin, D.P. and Drueckhammer, D.G.
    Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase.
    Biochem. Biophys. Res. Commun. 192 : 1155-1161 (1993). [PMID: 8389542]
  4. Geerlof, A., Lewendon, A. and Shaw, W.V.
    Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.
    J. Biol. Chem. 274 : 27105-27111 (1999). [PMID: 10480925]
  5. Izard, T., Geerlof, A., Lewendon, A. and Barker, J.J.
    Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli.
    Acta Crystallogr. D 55 : 1226-1228 (1999). [PMID: 10329792]

[EC created 1961, modified 2002]