EC - Mannose-1-phosphate guanylyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
mannose-1-phosphate guanylyltransferase
Other names:
GDP-mannose pyrophosphorylase
GTP-mannose-1-phosphate guanylyltransferase
PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)
guanosine 5'-diphospho-D-mannose pyrophosphorylase
guanosine diphosphomannose pyrophosphorylase
guanosine triphosphate-mannose 1-phosphate guanylyltransferase
mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
Systematic name:
GTP:α-D-mannose-1-phosphate guanylyltransferase



The bacterial enzyme can also use ITP and dGTP as donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004475
CAS Registry Number: 37278-24-3
UniProtKB/Swiss-Prot: (62) [show] [UniProt]


  1. Munch-Peterson, A.
    Enzymatic synthesis and phosphorolysis of guanosine diphosphate mannose.
    Arch. Biochem. Biophys. 55 : 592-593 (1955).
  2. Preiss, J. and Wood, E.
    Sugar nucleotide reactions in Arthrobacter. I. Guanosine diphosphate mannose pyrophosphorylase: purification and properties.
    J. Biol. Chem. 239 : 3119-3126 (1964). [PMID: 14245350]

[EC created 1961, modified 1976]