EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.6 - Diphosphotransferases
EC 18.104.22.168 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
IntEnz Enzyme Nomenclature
- ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
Binds 2 Mg2+ ions that are essential for activity . The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants, fungi, and some archaeal species, including the haloarchaea) and methanopterin (in some archaeal species such as the Archaeoglobi and Methanobacteria). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 22.214.171.124, dihydroneopterin aldolase , the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 126.96.36.199, dihydropteroate synthase , while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities .
Links to other databases
The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid.J. Biol. Chem. 244 : 1582-1592 (1969). [PMID: 4304228]
Hydroxymethyldihydropteridine pyrophosphokinase and dihydropteroate synthetase from Escherichia coli.Methods Enzymol. 18B : 765-771 (1971).
The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate.Biochemistry 8 : 5022-5028 (1969). [PMID: 4312465]
A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities.J. Bacteriol. 175 : 2214-2220 (1993). [PMID: 8385663]
Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 Å resolution.Structure 8 : 1049-1058 (2000). [PMID: 11080626]
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.Mol. Biol. Cell 15 : 3811-3828 (2004). [PMID: 15169867]
Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response.J. Biol. Chem. 282 : 10749-10761 (2007). [PMID: 17289662]
[EC 188.8.131.52 created 1972, modified 2015]