EC - Guanylate kinase

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IntEnz Enzyme Nomenclature


Accepted name:
guanylate kinase
Other names:
5'-GMP kinase
ATP:GMP phosphotransferase
GMP kinase
deoxyguanylate kinase
guanosine monophosphate kinase
Systematic name:
ATP:(d)GMP phosphotransferase



dGMP can also act as acceptor, and dATP can act as donor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00670
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004385
CAS Registry Number: 9026-59-9
UniProtKB/Swiss-Prot: (341) [show] [UniProt]


  1. Buccino, R.J., Jr. and Roth, J.S.
    Partial purification and properties of ATP:GMP phosphotransferase from rat liver. Arch.
    Biochem. Biophys. 132 : 49-61 (1969). [PMID: 4307347]
  2. Hiraga, S. and Sugino, Y.
    Nucleoside monophosphokinases of Escherichia coli infected and uninfected with an RNA phage.
    Biochim. Biophys. Acta 114 : 416-418 (1966).
  3. Griffith, T.J. and Helleiner, C.W.
    The partial purification of deoxynucleoside monophosphate kinases from L cells.
    Biochim. Biophys. Acta 108 : 114-124 (1965). [PMID: 5862227]
  4. Oeschger, M.P. and Bessman, M.J.
    Purification and properties of guanylate kinase from Escherichia coli.
    J. Biol. Chem. 241 : 5452-5460 (1966). [PMID: 5333666]
  5. Shimono, H. and Sugino, Y.
    Metabolism of deoxyribonucleotides. Purification and properties of deoxyguanosine monophosphokinase of calf thymus.
    Eur. J. Biochem. 19 : 256-263 (1971). [PMID: 5552394]

[EC created 1965]