EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.4 - Phosphotransferases with a phosphate group as acceptor
EC 2.7.4.23 - Ribose 1,5-bisphosphate phosphokinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.4.23
Names
Accepted name:
ribose 1,5-bisphosphate phosphokinase
Other
names:
ribose 1,5-bisphosphokinase
PhnN
ATP:ribose-1,5-bisphosphate phosphotransferase
PhnN
ATP:ribose-1,5-bisphosphate phosphotransferase
Systematic name:
ATP:α-D-ribose-1,5-bisphosphate phosphotransferase
Reaction
- ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate
Comments:
This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-α-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.
Links to other databases
Gene Ontology:
GO:0033863
References
-
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.J. Bacteriol. 185 : 2793-2801 (2003). [PMID: 12700258]
[EC 2.7.4.23 created 2006]