IntEnz

EC 2.7.4.23 - Ribose 1,5-bisphosphate phosphokinase

IntEnz Enzyme Nomenclature
EC 2.7.4.23

Names

Reaction

• 20109 [IUBMB]
  α-D-ribose 1,5-bisphosphate

  alpha-D-ribose 1,5-bisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:68688

  Formula: C5H8O11P2
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  5-phospho-α-D-ribose 1-diphosphate

  5-phospho-alpha-D-ribose 1-diphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58017

  Formula: C5H8O14P3
  Charge: -5

  ChEBI compound status: CHECKED (C)

  

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-α-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.

Links to other databases

References

1. Hove-Jensen, B., Rosenkrantz, T.J., Haldimann, A. and Wanner, B. L.
   Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
   J. Bacteriol. 185: 2793-2801 (2003). [PMID: 12700258]

[EC 2.7.4.23 created 2006]