EC 2.7.4.23 - Ribose 1,5-bisphosphate phosphokinase

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IntEnz Enzyme Nomenclature
EC 2.7.4.23

Names

Accepted name:
ribose 1,5-bisphosphate phosphokinase
Other names:
ribose 1,5-bisphosphokinase
PhnN
ATP:ribose-1,5-bisphosphate phosphotransferase
Systematic name:
ATP:α-D-ribose-1,5-bisphosphate phosphotransferase

Reaction

Comments:

This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-α-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033863
UniProtKB/Swiss-Prot: (40) [show] [UniProt]

References

  1. Hove-Jensen, B., Rosenkrantz, T.J., Haldimann, A. and Wanner, B. L.
    Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
    J. Bacteriol. 185: 2793-2801 (2003). [PMID: 12700258]

[EC 2.7.4.23 created 2006]