EC 22.214.171.124 - Aspartate kinase
IntEnz Enzyme Nomenclature
- ATP + L-aspartate = ADP + 4-phospho-L-aspartate
The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 126.96.36.199 homoserine dehydrogenase. This is also the case for two of the four isoenzymes in Arabidopsis thaliana. The equilibrium constant strongly favours the reaction from right to left, i.e. the non-physiological direction of reaction.
Links to other databases
Conversion of aspartic acid to homoserine.Methods Enzymol. 5 : 820-827 (1962).
Multivalent feedback inhibition of aspartokinase in Bacillus polymyxa. I. Kinetic studies.J. Biol. Chem. 242 : 4980-4986 (1967). [PMID: 6058940]
Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex.Biochemistry 11 : 677-687 (1972). [PMID: 4551091]
The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain.Eur. J. Biochem. 28 : 520-527 (1972). [PMID: 4562990]
[EC 188.8.131.52 created 1961]