EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.12 - Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
EC 2.7.12.1 - Dual-specificity kinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.12.1
Names
Accepted name:
dual-specificity kinase
Other
names:
ADK1
Arabidopsis dual specificity kinase 1
CLK1
dDYRK2
Mps1p
Arabidopsis dual specificity kinase 1
CLK1
dDYRK2
Mps1p
Systematic name:
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
Reactions
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17989 [IUBMB]ATPName origin: UniProt - CHECKED (C)Formula: C10H12N5O13P3
Charge: -4ChEBI compound status: CHECKED (C)L-seryl-[protein]GENERIC:9863Is ROOT: no
ROOT compound: GENERIC:9624Number of residues: 1=ADPName origin: UniProt - CHECKED (C)Formula: C10H12N5O10P2
Charge: -3ChEBI compound status: CHECKED (C)H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C) -
46608 [IUBMB]ATPName origin: UniProt - CHECKED (C)Formula: C10H12N5O13P3
Charge: -4ChEBI compound status: CHECKED (C)L-threonyl-[protein]GENERIC:11060Is ROOT: no
ROOT compound: GENERIC:9624Number of residues: 1=ADPName origin: UniProt - CHECKED (C)Formula: C10H12N5O10P2
Charge: -3ChEBI compound status: CHECKED (C)H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C) -
10596 [IUBMB]ATPName origin: UniProt - CHECKED (C)Formula: C10H12N5O13P3
Charge: -4ChEBI compound status: CHECKED (C)L-tyrosyl-[protein]GENERIC:10136Is ROOT: no
ROOT compound: GENERIC:9624Number of residues: 1=ADPName origin: UniProt - CHECKED (C)Formula: C10H12N5O10P2
Charge: -3ChEBI compound status: CHECKED (C)H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. Formerly EC 2.7.1.37.
Links to other databases
Protein domains and families:
PROSITE:PDOC00100
Gene Ontology:
GO:0004712
References
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Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.J. Biol. Chem. 269 : 31626-31629 (1994). [PMID: 7527390]
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Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.EMBO J. 14 : 1655-1663 (1995). [PMID: 7737118]
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Biochemical characterization and localization of the dual specificity kinase CLK1.J. Cell. Sci. 113 : 3241-3253 (2000). [PMID: 10954422]
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dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.Biochem. J. 374 : 381-391 (2003). [PMID: 12786602]
[EC 2.7.12.1 created 2005 (EC 2.7.1.37 part-incorporated 2005)]