EC - Dual-specificity kinase

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IntEnz Enzyme Nomenclature


Accepted name:
dual-specificity kinase
Other names:
Arabidopsis dual specificity kinase 1
Systematic name:
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)



This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00100
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004712
UniProtKB/Swiss-Prot: (129) [show] [UniProt]


  1. Ali, N., Halfter, U. and Chua, N.-H.
    Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.
    J. Biol. Chem. 269 : 31626-31629 (1994). [PMID: 7527390]
  2. Lauzé, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R. and Winey, M.
    Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.
    EMBO J. 14 : 1655-1663 (1995). [PMID: 7737118]
  3. Menegay, H.J., Myers, M.P., Moeslein, F.M. and Landreth, G.E.
    Biochemical characterization and localization of the dual specificity kinase CLK1.
    J. Cell. Sci. 113 : 3241-3253 (2000). [PMID: 10954422]
  4. Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K. and Cleghon, V.
    dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.
    Biochem. J. 374 : 381-391 (2003). [PMID: 12786602]

[EC created 2005 (EC part-incorporated 2005)]