IntEnz

EC 2.7.12.1 - Dual-specificity kinase

IntEnz Enzyme Nomenclature
EC 2.7.12.1

Names

Reactions

• 17989 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-seryl-[protein]

  L-seryl-[protein]

  GENERIC:9863

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-seryl-[protein]

  O-phospho-L-seryl-[protein]

  GENERIC:11604

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-serine residue O-phospho-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:83421 Formula: C3H4NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)
• 46608 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-threonyl-[protein]

  L-threonyl-[protein]

  GENERIC:11060

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-threonine residue L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:30013 Formula: C4H7NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho--L-threonyl-[protein]

  O-phospho--L-threonyl-[protein]

  GENERIC:11605

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-threonine residue O-phospho-L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:61977 Formula: C4H6NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)
• 10596 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-tyrosyl-[protein]

  L-tyrosyl-[protein]

  GENERIC:10136

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-tyrosine residue L-tyrosine residue Name origin: UniProt - CHECKED (C) CHEBI:46858 Formula: C9H9NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-tyrosyl-[protein]

  O-phospho-L-tyrosyl-[protein]

  GENERIC:10137

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-tyrosine-phosphate residue L-tyrosine-phosphate residue Name origin: UniProt - CHECKED (C) CHEBI:82620 Formula: C9H8NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. Formerly EC 2.7.1.37.

Links to other databases

References

1. Ali, N., Halfter, U. and Chua, N.-H.
   Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.
   J. Biol. Chem. 269: 31626-31629 (1994). [PMID: 7527390]
2. Lauzé, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R. and Winey, M.
   Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.
   EMBO J. 14: 1655-1663 (1995). [PMID: 7737118]
3. Menegay, H.J., Myers, M.P., Moeslein, F.M. and Landreth, G.E.
   Biochemical characterization and localization of the dual specificity kinase CLK1.
   J. Cell. Sci. 113: 3241-3253 (2000). [PMID: 10954422]
4. Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K. and Cleghon, V.
   dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.
   Biochem. J. 374: 381-391 (2003). [PMID: 12786602]

[EC 2.7.12.1 created 2005 (EC 2.7.1.37 part-incorporated 2005)]