EC - [isocitrate dehydrogenase (NADP+)] kinase

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IntEnz Enzyme Nomenclature


Accepted name:
[isocitrate dehydrogenase (NADP+)] kinase
Other names:
isocitrate dehydrogenase kinase (phosphorylating)
isocitrate dehydrogenase kinase/phosphatase
isocitrate dehydrogenase kinase
IDH kinase/phosphatase
[isocitrate dehydrogenase (NADP)] kinase
ICDH kinase/phosphatase
IDH kinase
Systematic name:
ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase



The enzyme has no activating compound but is specific for its substrate. Phosphorylates and inactivates EC, isocitrate dehydrogenase (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008772
CAS Registry Number: 83682-93-3
UniProtKB/Swiss-Prot: (122) [show] [UniProt]


  1. Wang, J.Y.J. and Koshland, D.E., Jr.
    The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium.
    Arch. Biochem. Biophys. 218: 59-67 (1982). [PMID: 6756316]
  2. Miller, S.P., Karschnia, E.J., Ikeda, T.P. and LaPorte, D.C.
    Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins.
    J. Biol. Chem. 271: 19124-19128 (1996). [PMID: 8702587]
  3. Singh, S.K., Matsuno, K., LaPorte, D.C. and Banaszak, L.J.
    Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 Å. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase.
    J. Biol. Chem. 276: 26154-26163 (2001). [PMID: 11290745]
  4. Oudot, C., Cortay, J.-C., Blanchet, C., LaPorte, D.C., Di Pietro, A., Cozzone, A.J. and Jault, J.-M.
    The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases.
    Biochemistry 40: 3047-3055 (2001). [PMID: 11258918]

[EC created 1986 as EC, transferred 2005 to EC]