EC 2.7.11.31 - [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

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IntEnz Enzyme Nomenclature
EC 2.7.11.31

Names

Accepted name:
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Other names:
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase
3-hydroxy-3-methylglutaryl-CoA reductase kinase
β-hydroxy-β-methylglutaryl-CoA reductase kinase
AMP-activated protein kinase
hydroxymethylglutaryl coenzyme A reductase kinase
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating)
hydroxymethylglutaryl-CoA reductase kinase
reductase kinase
AMPK
HMG-CoA reductase kinase
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase
STK29
Systematic name:
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase

Reaction

Comments:

The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH), is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (α-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047322
CAS Registry Number: 172522-01-9
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr.
    3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.
    Proc. Natl. Acad. Sci. USA 75: 3678-3682 (1978). [PMID: 278983]
  2. Gibson, D.M. and Ingebritsen, T.S.
    Reversible modulation of liver hydroxymethylglutaryl CoA reductase.
    Life Sci. 23: 2649-2664 (1978). [PMID: 216867]
  3. Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M.
    Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.
    Biochem. Biophys. Res. Commun. 81: 1268-1277 (1978). [PMID: 666819]
  4. Ferrer, A., Caelles, C., Massot, N. and Hegardt, F.G.
    Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.
    Biol. Chem. Hoppe-Seyler 368: 249-257 (1987). [PMID: 3689494]
  5. Weekes, J., Ball, K.L., Caudwell, F.B. and Hardie, D.G.
    Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.
    FEBS Lett. 334: 335-339 (1993). [PMID: 7902296]
  6. Crute, B.E., Seefeld, K., Gamble, J., Kemp, B.E. and Witters, L.A.
    Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.
    J. Biol. Chem. 273: 35347-35354 (1998). [PMID: 9857077]
  7. Stein, S.C., Woods, A., Jones, N.A., Davison, M.D. and Carling, D.
    The regulation of AMP-activated protein kinase by phosphorylation.
    Biochem. J. 345: 437-443 (2000). [PMID: 10642499]

[EC 2.7.11.31 created 1984 as EC 2.7.1.109, transferred 2005 to EC 2.7.11.31]