EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.11 - Protein-serine/threonine kinases
EC 2.7.11.30 - Receptor protein serine/threonine kinase
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ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.11.30
Names
Accepted name:
receptor protein serine/threonine kinase
Other
names:
activin receptor kinase
receptor type I serine/threonine protein kinase
receptor type II serine/threonine protein kinase
STK13
TGF-β kinase
receptor serine/threonine protein kinase
receptor type I serine/threonine protein kinase
receptor type II serine/threonine protein kinase
STK13
TGF-β kinase
receptor serine/threonine protein kinase
Systematic name:
ATP:[receptor-protein] phosphotransferase
Reaction
- ATP + receptor-protein = ADP + receptor-protein phosphate
Comments:
The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
Links to other databases
Protein domains and families:
PROSITE:PDOC00100
Gene Ontology:
GO:0004675
References
-
Mechanism of activation of the TGF-β receptor.Nature 370 : 341-347 (1994). [PMID: 8047140]
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Controlling TGF-β signaling.Genes Dev. 14 : 627-644 (2000). [PMID: 10733523]
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Characterization of functional domains within Smad4/DPC4.J. Biol. Chem. 272 : 13690-13696 (1997). [PMID: 9153220]
[EC 2.7.11.30 created 2005 (EC 2.7.1.37 part-incorporated 2005)]