IntEnz

EC 2.7.11.30 - Receptor protein serine/threonine kinase

IntEnz Enzyme Nomenclature
EC 2.7.11.30

Names

Reactions

• 18673 [IUBMB]
  [receptor-protein]-L-serine

  [receptor-protein]-L-serine

  GENERIC:11022

  Is ROOT: no
  ROOT compound: GENERIC:11021

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  [receptor-protein]-O-phospho-L-serine

  [receptor-protein]-O-phospho-L-serine

  GENERIC:11023

  Is ROOT: no
  ROOT compound: GENERIC:11021

  Number of residues: 1

  O-phospho-L-serine residue O-phospho-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:83421 Formula: C3H4NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 44880 [IUBMB]
  [receptor-protein]-L-threonine

  [receptor-protein]-L-threonine

  GENERIC:11024

  Is ROOT: no
  ROOT compound: GENERIC:11021

  Number of residues: 1

  L-threonine residue L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:30013 Formula: C4H7NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  [receptor-protein]-O-phospho-L-threonine

  [receptor-protein]-O-phospho-L-threonine

  GENERIC:11025

  Is ROOT: no
  ROOT compound: GENERIC:11021

  Number of residues: 1

  O-phospho-L-threonine residue O-phospho-L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:61977 Formula: C4H6NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].

Links to other databases

References

1. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J.
   Mechanism of activation of the TGF-β receptor.
   Nature 370: 341-347 (1994). [PMID: 8047140]
2. Massagué, J. and Chen, Y.-G.
   Controlling TGF-β signaling.
   Genes Dev. 14: 627-644 (2000). [PMID: 10733523]
3. de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B. and Lechleider, R.J.
   Characterization of functional domains within Smad4/DPC4.
   J. Biol. Chem. 272: 13690-13696 (1997). [PMID: 9153220]

[EC 2.7.11.30 created 2005 (EC 2.7.1.37 part-incorporated 2005)]