IntEnz

EC 2.7.11.23 - [RNA-polymerase]-subunit kinase

IntEnz Enzyme Nomenclature
EC 2.7.11.23

Names

Reaction

• 10216 [IUBMB]
  [DNA-directed RNA polymerase]

  [DNA-directed RNA polymerase]

  GENERIC:11321

  Is ROOT: no
  ROOT compound: GENERIC:11320

  Number of residues: 1

  hydroxy group hydroxy group Name origin: UniProt - CHECKED (C) CHEBI:43176 Formula: HO Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  phospho-[DNA-directed RNA polymerase]

  phospho-[DNA-directed RNA polymerase]

  GENERIC:11322

  Is ROOT: no
  ROOT compound: GENERIC:11320

  Number of residues: 1

  phosphate group phosphate group Name origin: UniProt - CHECKED (C) CHEBI:68546 Formula: O4P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

The enzyme appears to be distinct from other protein phosphokinases. It brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.

Links to other databases

References

1. Lee, J.M. and Greenleaf, A.L.
   A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.
   Proc. Natl. Acad. Sci. USA 86: 3624-3628 (1989). [PMID: 2657724]

[EC 2.7.11.23 created 1992 as EC 2.7.1.141, transferred 2005 to EC 2.7.11.23]