EC 2.7.11.23 - [RNA-polymerase]-subunit kinase

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IntEnz Enzyme Nomenclature
EC 2.7.11.23

Names

Accepted name:
[RNA-polymerase]-subunit kinase
Other names:
CTD kinase
STK9
Systematic name:
ATP:[DNA-directed RNA polymerase] phosphotransferase

Reaction

Comments:

The enzyme appears to be distinct from other protein phosphokinases. It brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00100
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008353
CAS Registry Number: 122097-00-1
UniProtKB/Swiss-Prot: (152) [show] [UniProt]

References

  1. Lee, J.M. and Greenleaf, A.L.
    A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.
    Proc. Natl. Acad. Sci. USA 86: 3624-3628 (1989). [PMID: 2657724]

[EC 2.7.11.23 created 1992 as EC 2.7.1.141, transferred 2005 to EC 2.7.11.23]