IntEnz

EC 2.7.11.22 - Cyclin-dependent kinase

IntEnz Enzyme Nomenclature
EC 2.7.11.22

Names

Reactions

• 17989 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-seryl-[protein]

  L-seryl-[protein]

  GENERIC:9863

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-seryl-[protein]

  O-phospho-L-seryl-[protein]

  GENERIC:11604

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-serine residue O-phospho-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:83421 Formula: C3H4NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)
• 46608 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-threonyl-[protein]

  L-threonyl-[protein]

  GENERIC:11060

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-threonine residue L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:30013 Formula: C4H7NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-threonyl-[protein]

  O-phospho-L-threonyl-[protein]

  GENERIC:11605

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-threonine residue O-phospho-L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:61977 Formula: C4H6NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. Formerly EC 2.7.1.37.

Links to other databases

References

1. Johnson, D.G. and Walker, C.L.
   Cyclins and cell cycle checkpoints.
   Annu. Rev. Pharmacol. Toxicol. 39 : 295-312 (1999). [PMID: 10331086]
2. Pan, Z.Q., Amin, A., and Hurwitz, J.
   Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities.
   J. Biol. Chem. 268 : 20443-20451 (1993). [PMID: 8397207]
3. Yee, A., Wu, L., Liu, L., Kobayashi, R., Xiong, Y. and Hall, F.L.
   Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit.
   J. Biol. Chem. 271 : 471-477 (1996). [PMID: 8550604]

[EC 2.7.11.22 created 2005 (EC 2.7.1.37 part-incorporated 2005)]