EC - [pyruvate dehydrogenase (acetyl-transferring)] kinase

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IntEnz Enzyme Nomenclature


Accepted name:
[pyruvate dehydrogenase (acetyl-transferring)] kinase
Other names:
pyruvate dehydrogenase kinase
pyruvate dehydrogenase kinase (phosphorylating)
PDH kinase
pyruvate dehydrogenase kinase activator protein
Systematic name:
ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase



The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC, pyruvate dehydrogenase (acetyl-transferring).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50109
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004740
CAS Registry Number: 9074-01-5
UniProtKB/Swiss-Prot: (20) [show] [UniProt]


  1. Linn, T.C., Pelley, J.W., Petit, F.H., Hucho, F., Randall, D.D. and Reed, L.J.
    α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
    Arch. Biochem. Biophys. 148: 327-342 (1972). [PMID: 4401694]
  2. Reed, L.J., Damuni, Z. and Merryfield, M.L.
    Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
    Curr. Top. Cell. Regul. 27: 41-49 (1985). [PMID: 3004826]
  3. Tovar-Méndez, A., Hirani, T.A., Miernyk, J.A. and Randall, D.D.
    Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase.
    Arch. Biochem. Biophys. 434: 159-168 (2005). [PMID: 15629119]
  4. Bao, H., Kasten, S.A., Yan, X., Hiromasa, Y. and Roche, T.E.
    Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
    Biochemistry 43: 13442-13451 (2004). [PMID: 15491151]
  5. Roche, T.E., Hiromasa, Y., Turkan, A., Gong, X., Peng, T., Yan, X., Kasten, S.A., Bao, H. and Dong, J.
    Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
    Eur. J. Biochem. 270: 1050-1056 (2003). [PMID: 12631265]

[EC created 1978 as EC, transferred 2005 to EC]