IntEnz

EC 2.7.11.13 - Protein kinase C

IntEnz Enzyme Nomenclature
EC 2.7.11.13

Names

Reactions

• 17989 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-seryl-[protein]

  L-seryl-[protein]

  GENERIC:9863

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-seryl-[protein]

  O-phospho-L-seryl-[protein]

  GENERIC:11604

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-serine residue O-phospho-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:83421 Formula: C3H4NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)
• 46608 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-threonyl-[protein]

  L-threonyl-[protein]

  GENERIC:11060

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-threonine residue L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:30013 Formula: C4H7NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-threonyl-[protein]

  O-phospho-L-threonyl-[protein]

  GENERIC:11605

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-threonine residue O-phospho-L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:61977 Formula: C4H6NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters. Formerly EC 2.7.1.37.

Links to other databases

References

1. Jaken, S.
   Protein kinase C and tumor promoters.
   Curr. Opin. Cell Biol. 2 : 192-197 (1990). [PMID: 2194521]
2. Parekh, D.B., Ziegler, W. and Parker, P. J.
   Multiple pathways control protein kinase C phosphorylation.
   EMBO J. 19 : 496-503 (2000). [PMID: 10675318]
3. Valledor, A.F., Xaus, J., Comalada, M., Soler, C. and Celada, A.
   Protein kinase Cε is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.
   J. Immunol. 164 : 29-37 (2000). [PMID: 10604989]
4. Lendenfeld, T. and Kubicek, C.P.
   Characterization and properties of protein kinase C from the filamentous fungus Trichoderma reesei.
   Biochem. J. 330 : 689-694 (1998). [PMID: 9480876]
5. Brooks, S.P. and Storey, K.B.
   Protein kinase C from rainbow trout brain: identification and characterization of three isozymes.
   Biochem. Mol. Biol. Int. 44 : 259-267 (1998). [PMID: 9530509]

[EC 2.7.11.13 created 2005 (EC 2.7.1.37 part-incorporated 2005)]