IntEnz

EC 2.7.11.11 - CAMP-dependent protein kinase

IntEnz Enzyme Nomenclature
EC 2.7.11.11

Names

Reactions

• 17989 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-seryl-[protein]

  L-seryl-[protein]

  GENERIC:9863

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-seryl-[protein]

  O-phospho-L-seryl-[protein]

  GENERIC:11604

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-serine residue O-phospho-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:83421 Formula: C3H4NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)
• 46608 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  L-threonyl-[protein]

  L-threonyl-[protein]

  GENERIC:11060

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-threonine residue L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:30013 Formula: C4H7NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  O-phospho-L-threonyl-[protein]

  O-phospho-L-threonyl-[protein]

  GENERIC:11605

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  O-phospho-L-threonine residue O-phospho-L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:61977 Formula: C4H6NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

cAMP is required to activate this enzyme. The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits [i.e. R₂C₂ + 4 cAMP = R₂(cAMP)₄ + 2 C]. Formerly EC 2.7.1.37.

Links to other databases

References

1. Technikova-Dobrova, Z., Sardanelli, A.M., Speranza, F., Scacco, S., Signorile, A., Lorusso, V. and Papa, S.
   Cyclic adenosine monophosphate-dependent phosphorylation of mammalian mitochondrial proteins: enzyme and substrate characterization and functional role.
   Biochemistry 40: 13941-13947 (2001). [PMID: 11705384]
2. Andersen, M.D., Shaffer, J., Jennings, P.A. and Adams, J.A.
   Structural characterization of protein kinase A as a function of nucleotide binding. Hydrogen-deuterium exchange studies using matrix-assisted laser desorption ionization-time of flight mass spectrometry detection.
   J. Biol. Chem. 276: 14204-14211 (2001). [PMID: 11278927]
3. Johnson, K.E., Cameron, S., Toda, T., Wigler, M. and Zoller, M.J.
   Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization.
   J. Biol. Chem. 262: 8636-8642 (1987). [PMID: 3036817]
4. Haq, E., Sharma, S. and Khuller, G.K.
   Purification and characterization of cAMP dependent protein kinase from Microsporum gypseum.
   Biochim. Biophys. Acta 1474: 100-106 (2000). [PMID: 10699496]

[EC 2.7.11.11 created 2005 (EC 2.7.1.37 part-incorporated 2005)]