IntEnz

EC 2.7.11.10 - IκB kinase

IntEnz Enzyme Nomenclature
EC 2.7.11.10

Names

Reaction

• 19073 [IUBMB]
  [I-kappa-B protein]-L-serine

  [I-kappa-B protein]-L-serine

  GENERIC:13698

  Is ROOT: no
  ROOT compound: GENERIC:13697

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  [I-kappa-B protein]-O-phospho-L-serine

  [I-kappa-B protein]-O-phospho-L-serine

  GENERIC:13699

  Is ROOT: no
  ROOT compound: GENERIC:13697

  Number of residues: 1

  O-phospho-L-serine residue O-phospho-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:83421 Formula: C3H4NO5P Charge: -2 Position: undefined ChEBI compound status: CHECKED (C)

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme phosphorylates IκB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IκB complex (IKK) activates NF-κB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.

Links to other databases

References

1. Regnier, C. H., Song, H.Y., Gao, X., Goeddel, D.V., Cao, Z. and Rothe, M.
   Identification and characterization of an IκB kinase.
   Cell 90: 373-383 (1997). [PMID: 9244310]
2. Mercurio, F., Zhu, H., Murray, B.W., Shevchenko, A., Bennett, B.L., Li, J., Young, D.B., Barbosa, M., Mann, M., Manning, A. and Rao, A.
   IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation.
   Science 278: 860-866 (1997). [PMID: 9346484]
3. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., Karin, M.
   The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation.
   Cell 91: 243-252 (1997). [PMID: 9346241]
4. Viatour, P., Merville, M.P., Bours, V. and Chariot, A.
   Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation.
   Trends Biochem. Sci. 30: 43-52 (2005). [PMID: 15653325]

[EC 2.7.11.10 created 2005 (EC 2.7.1.37 part-incorporated 2005)]