EC 2.7.10.2 - Non-specific protein-tyrosine kinase

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IntEnz Enzyme Nomenclature
EC 2.7.10.2

Names

Accepted name:
non-specific protein-tyrosine kinase
Other names:
ABL
ABL1
ABL2
ABLL
ACK1
ACK2
AGMX1
ARG
ATK
ATP:protein-tyrosine O-phosphotransferase [ambiguous]
BLK
Bmk
BMX
BRK
Bruton's tyrosine kinase
Bsk
BTK
BTKL
CAKb
Cdgip
CHK
CSK
CTK
CYL
cytoplasmic protein tyrosine kinase
EMT
ETK
Fadk
FAK
FAK2
FER
Fert1/2
FES
FGR
focal adhesion kinase
FPS
FRK
FYN
HCK
HCTK
HYL
IMD1
ITK
IYK
JAK1
JAK2
JAK3
Janus kinase 1
Janus kinase 2
Janus kinase 3
JTK1
JTK9
L-JAK
LCK
LSK
LYN
MATK
Ntk
p60c-src protein tyrosine kinase
PKB
protein-tyrosine kinase [ambiguous]
PSCTK
PSCTK1
PSCTK2
PSCTK4
PSCTK5
PTK2
PTK2B
PTK6
PYK2
RAFTK
RAK
Rlk
Sik
SLK
SRC
SRC2
SRK
SRM
SRMS
STD
SYK
SYN
Tck
TEC
TNK1
Tsk
TXK
TYK2
TYK3
YES1
YK2
ZAP70
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)

Reaction

Comments:

Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00100
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004715
UniProtKB/Swiss-Prot: (225) [show] [UniProt]

References

  1. Robinson, D.R., Wu, Y.-M. and Lin, S.-F.
    The protein tyrosine kinase family of the human genome.
    Oncogene 19: 5548-5557 (2000). [PMID: 11114734]
  2. Roskoski, R., Jr.
    Src protein-tyrosine kinase structure and regulation.
    Biochem. Biophys. Res. Commun. 324: 1155-1164 (2004). [PMID: 15504335]

[EC 2.7.10.2 created 1984 as EC 2.7.1.112, part-transferred 2005 to EC 2.7.10.2]