EC - Sphingosine kinase

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IntEnz Enzyme Nomenclature


Accepted name:
sphingosine kinase
Other names:
dihydrosphingosine kinase
dihydrosphingosine kinase (phosphorylating)
sphingosine kinase (phosphorylating)
SPHK1 (gene name)
SPHK2 (gene name)
sphingoid base kinase
sphinganine kinase
ATP:sphinganine 1-phosphotransferase
Systematic name:
ATP:sphingoid base 1-phosphotransferase



The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50146
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008481
CAS Registry Number: 50864-48-7
UniProtKB/Swiss-Prot: (25) [show] [UniProt]


  1. Stoffel, W., Bauer, E. and Stahl, J.
    The metabolism of sphingosine bases in Tetrahymena pyriformis. Sphingosine kinase and sphingosine-1-phosphate lyase.
    Hoppe-Seyler's Z. Physiol. Chem. 355 : 61-74 (1974). [PMID: 4373374]
  2. Stoffel, W., Heimann, G. and Hellenbroich, B.
    Sphingosine kinase in blood platelets.
    Hoppe-Seyler's Z. Physiol. Chem. 354 : 562-566 (1973). [PMID: 4372149]
  3. Nagiec, M. M., Skrzypek, M., Nagiec, E. E., Lester, R. L., Dickson, R. C.
    The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.
    J. Biol. Chem. 273 : 19437-19442 (1998). [PMID: 9677363]
  4. Kohama, T., Olivera, A., Edsall, L., Nagiec, M. M., Dickson, R., Spiegel, S.
    Molecular cloning and functional characterization of murine sphingosine kinase.
    J. Biol. Chem. 273 : 23722-23728 (1998). [PMID: 9726979]
  5. Liu, H., Sugiura, M., Nava, V. E., Edsall, L. C., Kono, K., Poulton, S., Milstien, S., Kohama, T., Spiegel, S.
    Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
    J. Biol. Chem. 275 : 19513-19520 (2000). [PMID: 10751414]
  6. Worrall, D., Liang, Y. K., Alvarez, S., Holroyd, G. H., Spiegel, S., Panagopulos, M., Gray, J. E., Hetherington, A. M.
    Involvement of sphingosine kinase in plant cell signalling.
    Plant J. 56 : 64-72 (2008). [PMID: 18557834]

[EC created 1976, modified 1980, modified 2016]