EC - 1-phosphatidylinositol-4-phosphate 5-kinase

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IntEnz Enzyme Nomenclature


Accepted name:
1-phosphatidylinositol-4-phosphate 5-kinase
Other names:
PIP kinase
diphosphoinositide kinase
phosphatidylinositol 4-phosphate kinase
phosphatidylinositol-4-phosphate 5-kinase
type I PIP kinase
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase



This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016308
CAS Registry Number: 104645-76-3
UniProtKB/Swiss-Prot: (27) [show] [UniProt]


  1. Kai, M., Salway, J.G. and Hawthorne, J.N.
    The diphosphoinositide kinase of rat brain.
    Biochem. J. 106: 791-801 (1968). [PMID: 4295336]
  2. Kai, M., Salway, J.G., Michell, R.H. and Hawthorne, J.N.
    The biosynthesis of triphosphoinositide by rat brain in vitro.
    Biochem. Biophys. Res. Commun. 22: 370-375 (1966).
  3. Rameh, L.E., Tolias, K.F., Duckworth, B.C. and Cantley, L.C.
    A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
    Nature 390: 192-196 (1997). [PMID: 9367159]

[EC created 1972, modified 1980, modified 1982, modified 2002]