EC - 1-phosphatidylinositol 4-kinase

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IntEnz Enzyme Nomenclature


Accepted name:
1-phosphatidylinositol 4-kinase
Other names:
PI 4-kinase
PI kinase
phosphatidylinositol 4-kinase
phosphatidylinositol kinase
phosphatidylinositol kinase (phosphorylating)
type II phosphatidylinositol kinase
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase



This reaction is catalysed by at least two different isoforms.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00710
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004430
CAS Registry Number: 37205-54-2
UniProtKB/Swiss-Prot: (54) [show] [UniProt]


  1. Colodzin, M. and Kennedy, E.P.
    Biosynthesis of diphosphoinositide in brain.
    J. Biol. Chem. 240: 3771-3780 (1965). [PMID: 4284712]
  2. Kai, M., White, G.L. and Hawthorne, J.N.
    The phosphatidylinositol kinase of rat brain.
    Biochem. J. 101: 328-337 (1966). [PMID: 4290722]
  3. Walker, D.H., Dougherty, N. and Pike, L.J.
    Purification and characterization of a phosphatidylinositol kinase from A431 cells.
    Biochemistry 27: 6504-6511 (1988). [PMID: 2851325]
  4. Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L.
    Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
    Nature 332: 644-646 (1988). [PMID: 2833705]
  5. Barylko, B., Gerber, S.H., Binns, D.D., Grichine, N., Khvotchev, M., Sudhof, T.C. and Albanesi, J.P.
    A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.
    J. Biol. Chem. 276: 7705-7708 (2001). [PMID: 11244087]

[EC created 1972, modified 1982, modified 2002]