EC 2.7.1.6 - Galactokinase

  IntEnz view ENZYME view
XML

IntEnz Enzyme Nomenclature
EC 2.7.1.6

Names

Accepted name:
galactokinase
Other names:
ATP:D-galactose-1-phosphotransferase
galactokinase (phosphorylating)
Systematic name:
ATP:α-D-galactose 1-phosphotransferase

Reaction

Comments:

Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-α-D-galactosamine [4-6].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00099 , PROSITE:PDOC00545
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004335
CAS Registry Number: 9030-53-9
UniProtKB/Swiss-Prot: (146) [show] [UniProt]

References

  1. Cardini, C.E. and Leloir, L.F.
    Enzymic phosphorylation of galactosamine and galactose.
    Arch. Biochem. Biophys. 45 : 55-64 (1953). [PMID: 13058412]
  2. Neufeld, E.F., Feingold, D.S. and Hassid, W.Z.
    Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings.
    J. Biol. Chem. 235 : 906-909 (1960). [PMID: 14426659]
  3. Wilkinson, J.F.
    The pathway of the adaptive fermentation of galactose by yeast.
    Biochem. J. 44 : 460-467 (1949). [PMID: 16748546]
  4. Yang, J., Fu, X., Jia, Q., Shen, J., Biggins, J. B., Jiang, J., Zhao, J., Schmidt, J. J., Wang, P. G., Thorson, J. S.
    Studies on the substrate specificity of Escherichia coli galactokinase.
    Org. Lett. 5 : 2223-2226 (2003). [PMID: 12816414]
  5. Timson, D. J., Reece, R. J.
    Sugar recognition by human galactokinase.
    BMC Biochem. 4 : 16 (2003). [PMID: 14596685]
  6. Thoden, J. B., Timson, D. J., Reece, R. J., Holden, H. M.
    Molecular structure of human galactokinase: implications for type II galactosemia.
    J. Biol. Chem. 280 : 9662-9670 (2005). [PMID: 15590630]

[EC 2.7.1.6 created 1961]