EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.6 - Galactokinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.6
Names
Accepted name:
galactokinase
Other
names:
ATP:D-galactose-1-phosphotransferase
galactokinase (phosphorylating)
galactokinase (phosphorylating)
Systematic name:
ATP:α-D-galactose 1-phosphotransferase
Reaction
- ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
Comments:
Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-α-D-galactosamine [4-6].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00099
,
PROSITE:PDOC00545
Gene Ontology:
GO:0004335
CAS Registry Number:
9030-53-9
References
-
Enzymic phosphorylation of galactosamine and galactose.Arch. Biochem. Biophys. 45 : 55-64 (1953). [PMID: 13058412]
-
Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings.J. Biol. Chem. 235 : 906-909 (1960). [PMID: 14426659]
-
The pathway of the adaptive fermentation of galactose by yeast.Biochem. J. 44 : 460-467 (1949). [PMID: 16748546]
-
Studies on the substrate specificity of Escherichia coli galactokinase.Org. Lett. 5 : 2223-2226 (2003). [PMID: 12816414]
-
Sugar recognition by human galactokinase.BMC Biochem. 4 : 16 (2003). [PMID: 14596685]
-
Molecular structure of human galactokinase: implications for type II galactosemia.J. Biol. Chem. 280 : 9662-9670 (2005). [PMID: 15590630]
[EC 2.7.1.6 created 1961]