IntEnz - EC 2.7.1.48

EC 2 - Transferases

EC 2.7 - Transferring phosphorus-containing groups

EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor

EC 2.7.1.48 - Uridine kinase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.7.1.48

Names

Accepted name:

uridine kinase

Other names:

pyrimidine ribonucleoside kinase
uridine kinase (phosphorylating)
uridine phosphokinase
uridine-cytidine kinase
uridine monophosphokinase

Systematic name:

ATP:uridine 5'-phosphotransferase

Reactions

16825 [IUBMB]

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

uridine

uridine

Name origin: UniProt - CHECKED (C)

CHEBI:16704

Formula: C9H12N2O6
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

UMP

UMP

Name origin: UniProt - CHECKED (C)

CHEBI:57865

Formula: C9H11N2O9P
Charge: -2

ChEBI compound status: CHECKED (C)
24674

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

cytidine

cytidine

Name origin: UniProt - CHECKED (C)

CHEBI:17562

Formula: C9H13N3O5
Charge: 0

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

CMP

CMP

Name origin: UniProt - CHECKED (C)

CHEBI:60377

Formula: C9H12N3O8P
Charge: -2

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

Comments:

Cytidine can act as acceptor; GTP and ITP can act as donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004849

CAS Registry Number: 9026-39-5

UniProtKB/Swiss-Prot: (234) [show] [UniProt]

References

Orengo, A.

Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor.

J. Biol. Chem. 244: 2204-2209 (1969). [PMID: 5782006]
Sköld, O.

Uridine kinase from Erlich ascites tumor: purification and properties.

J. Biol. Chem. 235: 3273-3279 (1960).
Suzuki, N. N., Koizumi, K., Fukushima, M., Matsuda, A., Inagaki, F.

Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase.

Structure 12: 751-764 (2004). [PMID: 15130468]
Pasti, C., Gallois-Montbrun, S., Munier-Lehmann, H., Veron, M., Gilles, A. M., Deville-Bonne, D.

Reaction of human UMP-CMP kinase with natural and analog substrates.

Eur. J. Biochem. 270: 1784-1790 (2003). [PMID: 12694191]

[EC 2.7.1.48 created 1965]