EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.40 - Pyruvate kinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.40
Names
Accepted name:
pyruvate kinase
Other
names:
phosphoenol transphosphorylase
phosphoenolpyruvate kinase
phosphoenolpyruvate kinase
Systematic name:
ATP:pyruvate 2-O-phosphotransferase
Reaction
- ATP + pyruvate = ADP + phosphoenolpyruvate
Comments:
UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00101
Gene Ontology:
GO:0004743
CAS Registry Number:
9001-59-6
References
-
Pyruvate kinase.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 6 , Academic Press , New York , 1962 , 95-113
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Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside.J. Biol. Chem. 193 : 481-495 (1951). [PMID: 14907737]
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Isolierung von Gärungsfermenten aus menschlichen Muskeln.Biochem. Z. 317 : 193-203 (1944).
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Enzymatic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction.Biochim. Biophys. Acta 16 : 616-618 (1955). [PMID: 14389299]
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"Fluorokinase" and pyruvic kinase.Arch. Biochem. Biophys. 78 : 477-493 (1958). [PMID: 13618030]
[EC 2.7.1.40 created 1961]