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EC 2.7.1.40 - Pyruvate kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.40

Names

Accepted name:

pyruvate kinase

Other names:

phosphoenol transphosphorylase
phosphoenolpyruvate kinase

Systematic name:

ATP:pyruvate 2-O-phosphotransferase

Reactions

18157 [IUBMB]

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

pyruvate

pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:15361

Formula: C3H3O3
Charge: -1

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphoenolpyruvate

phosphoenolpyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:58702

Formula: C3H2O6P
Charge: -3

ChEBI compound status: CHECKED (C)
30295

GTP

GTP

Name origin: UniProt - CHECKED (C)

CHEBI:37565

Formula: C10H12N5O14P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

pyruvate

pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:15361

Formula: C3H3O3
Charge: -1

ChEBI compound status: CHECKED (C)

=

GDP

GDP

Name origin: UniProt - CHECKED (C)

CHEBI:58189

Formula: C10H12N5O11P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphoenolpyruvate

phosphoenolpyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:58702

Formula: C3H2O6P
Charge: -3

ChEBI compound status: CHECKED (C)
56948

pyruvate

pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:15361

Formula: C3H3O3
Charge: -1

ChEBI compound status: CHECKED (C)

+

UTP

UTP

Name origin: UniProt - CHECKED (C)

CHEBI:46398

Formula: C9H11N2O15P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphoenolpyruvate

phosphoenolpyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:58702

Formula: C3H2O6P
Charge: -3

ChEBI compound status: CHECKED (C)

+

UDP

UDP

Name origin: UniProt - CHECKED (C)

CHEBI:58223

Formula: C9H11N2O12P2
Charge: -3

ChEBI compound status: CHECKED (C)
56952

CTP

CTP

Name origin: UniProt - CHECKED (C)

CHEBI:37563

Formula: C9H12N3O14P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

pyruvate

pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:15361

Formula: C3H3O3
Charge: -1

ChEBI compound status: CHECKED (C)

=

CDP

CDP

Name origin: UniProt - CHECKED (C)

CHEBI:58069

Formula: C9H12N3O11P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphoenolpyruvate

phosphoenolpyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:58702

Formula: C3H2O6P
Charge: -3

ChEBI compound status: CHECKED (C)
56956

ITP

ITP

Name origin: UniProt - CHECKED (C)

CHEBI:61402

Formula: C10H11N4O14P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

pyruvate

pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:15361

Formula: C3H3O3
Charge: -1

ChEBI compound status: CHECKED (C)

=

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

IDP

IDP

Name origin: UniProt - CHECKED (C)

CHEBI:58280

Formula: C10H11N4O11P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

phosphoenolpyruvate

phosphoenolpyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:58702

Formula: C3H2O6P
Charge: -3

ChEBI compound status: CHECKED (C)
30727

dATP

dATP

Name origin: UniProt - CHECKED (C)

CHEBI:61404

Formula: C10H12N5O12P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

pyruvate

pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:15361

Formula: C3H3O3
Charge: -1

ChEBI compound status: CHECKED (C)

=

dADP

dADP

Name origin: UniProt - CHECKED (C)

CHEBI:57667

Formula: C10H12N5O9P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphoenolpyruvate

phosphoenolpyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:58702

Formula: C3H2O6P
Charge: -3

ChEBI compound status: CHECKED (C)

Comments:

UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO₂.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway

Protein domains and families: PROSITE:PDOC00101

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004743

CAS Registry Number: 9001-59-6

UniProtKB/Swiss-Prot: (111) [show] [UniProt]

References

Boyer, P.D.

Pyruvate kinase.

In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 6, Academic Press, New York, 1962, 95-113
Kornberg, A. and Pricer, W.E.

Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside.

J. Biol. Chem. 193: 481-495 (1951). [PMID: 14907737]
Kubowitz, F. and Ott, P.

Isolierung von Gärungsfermenten aus menschlichen Muskeln.

Biochem. Z. 317: 193-203 (1944).
Strominger, J.L.

Enzymatic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction.

Biochim. Biophys. Acta 16: 616-618 (1955). [PMID: 14389299]
Tietz, A. and Ochoa, S.

"Fluorokinase" and pyruvic kinase.

Arch. Biochem. Biophys. 78: 477-493 (1958). [PMID: 13618030]

[EC 2.7.1.40 created 1961]

EC 2 - Transferases