EC - Pyruvate kinase

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IntEnz Enzyme Nomenclature


Accepted name:
pyruvate kinase
Other names:
phosphoenol transphosphorylase
phosphoenolpyruvate kinase
Systematic name:
ATP:pyruvate 2-O-phosphotransferase



UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00101
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004743
CAS Registry Number: 9001-59-6
UniProtKB/Swiss-Prot: (111) [show] [UniProt]


  1. Boyer, P.D.
    Pyruvate kinase.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 6, Academic Press, New York, 1962, 95-113
  2. Kornberg, A. and Pricer, W.E.
    Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside.
    J. Biol. Chem. 193: 481-495 (1951). [PMID: 14907737]
  3. Kubowitz, F. and Ott, P.
    Isolierung von Gärungsfermenten aus menschlichen Muskeln.
    Biochem. Z. 317: 193-203 (1944).
  4. Strominger, J.L.
    Enzymatic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction.
    Biochim. Biophys. Acta 16: 616-618 (1955). [PMID: 14389299]
  5. Tietz, A. and Ochoa, S.
    "Fluorokinase" and pyruvic kinase.
    Arch. Biochem. Biophys. 78: 477-493 (1958). [PMID: 13618030]

[EC created 1961]