IntEnz

EC 2.7.1.21 - Thymidine kinase

IntEnz Enzyme Nomenclature
EC 2.7.1.21

Names

Reaction

• 19129 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  thymidine

  thymidine

  Name origin: UniProt - CHECKED (C)

  CHEBI:17748

  Formula: C10H14N2O5
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  dTMP

  dTMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:63528

  Formula: C10H13N2O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP-thymidine kinase), EC 2.7.1.118 (ADP-thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).

Links to other databases

References

1. Falke, D., Labenz, J., Brauer, D. and Muller, W.E.G.
   Adenosine diphosphate: thymidine 5'-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase.
   Biochim. Biophys. Acta 708: 99-103 (1982). [PMID: 6293576]
2. Kizer, D.E. and Holman, L.
   Purification and properties of thymidine kinase from regenerating rat liver.
   Biochim. Biophys. Acta 350: 193-200 (1974). [PMID: 4407348]
3. Okazaki, R. and Kornberg, A.
   Deoxythymidine kinase of Escherichia coli. I. Purification and some properties of the enzyme.
   J. Biol. Chem. 239: 269-274 (1964). [PMID: 14114853]

[EC 2.7.1.21 created 1961, deleted 1972, reinstated 1976 (EC 2.7.1.75 created 1972, incorporated 1976)]